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Peptide record

TPDB03435

Antibacterial Anticancer Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB03435
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RPFTRAQWFAIQHISPRTIAMRAINNYRWR
Physicochemical Analysis
C171H262N56O39S1
DCEGLKV
R
3758.37
12.70
7
0
14
+6
0.08
-0.667
65.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
332.32
8
Residue Composition
number
4
A
6
R
2
N
0
D
0
C
0
E
2
Q
0
G
1
H
4
I
0
L
0
K
1
M
2
F
2
P
1
S
2
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 6 N: 2 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 4 L: 0 K: 0 M: 1 F: 2 P: 2 S: 1 T: 2 W: 2 Y: 1 V: 0
Chemical Descriptors
30
C171H262N56O39S1
3758.37
12.70
+6
0.08
-0.667
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
178.33±81.72 µM
Hemolytic Cytotoxic
50% Hemolysis | 178.33±81.72 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Evidence 2 Activity

Activity

IC50
Toxicity
>150 µM
Cytotoxic
IC50 | >150 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Positional scanning library applied to the human eosinophil cationic protein/RNase3 N-terminus reveals novel and potent anti-biofilm peptides. | Eur J Med Chem | 2018
Evidence 3 Activity

Activity

44±4% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
44±4% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021
Evidence 4 Activity

Activity

IC50
Toxicity
23±4 µM
Cytotoxic
IC50 | 23±4 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021
Evidence 5 Activity

Activity

IC50
Toxicity
150 µM
Hemolytic Cytotoxic
Hemolytic_activity: Sheep erythrocytes: 50% Hemolysis=178.33±81.72 µM Horse erythrocytes: 44±4% Hemolysis=250 µM | Cytotoxicity: MRC-5: IC50>150 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2018 May 25 152:590-599.