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Peptide record

TPDB03419

Antibacterial Antifungal Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB03419
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic Hemolytic2
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
QLPICGETCVLGGCYTPNCRCQYPICVR
Physicochemical Analysis
C130H209N37O38S6
ADHKMFSW
C
3090.67
7.62
2
1
8
+1
1.96
0.250
76.43
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
3355
108.55
13
Residue Composition
number
0
A
2
R
1
N
0
D
6
C
1
E
2
Q
3
G
0
H
2
I
2
L
0
K
0
M
0
F
3
P
0
S
2
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 6 E: 1 Q: 2 G: 3 H: 0 I: 2 L: 2 K: 0 M: 0 F: 0 P: 3 S: 0 T: 2 W: 0 Y: 2 V: 2
Chemical Descriptors
28
C130H209N37O38S6
3090.67
7.62
+1
1.96
0.250
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 (MIC 2.5 uM). Toxicity: 50% hemolysis at 15 uM (HC50=15 uM), highly hemolytic. Cytotoxic to hela cells
Evidence 2 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 (MIC 2.5 uM). Toxicity: 50% hemolysis at 15 uM (HC50=15 uM), highly hemolytic. Cytotoxic to hela cells
Evidence 3 Activity

Activity

IC50
Toxicity
6.0 µM
Cytotoxic
Cytotoxicity: [Ref.23195955] IC50 = 6.0 µM against HeLa cells.

Source & Reference

NA
DRAMP
J Biol Chem. 2013 Feb 1 288(5):3370-3380.
Evidence 4 Hemolysis

Source & Reference

APD_complete APD_hemolytic
APD_complete APD_hemolytic

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.