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Peptide record

TPDB03418

Antibacterial Antiparasitic Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB03418
Antibacterial Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Antiparasitic, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
GILKTIKSIASKVANTVQKLKRKAKNAV
Physicochemical Analysis
C134H247N41O36
DCEHMFPWY
K
3008.69
11.93
8
0
12
+8
7.19
-0.171
115.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
7
Residue Composition
number
4
A
1
R
2
N
0
D
0
C
0
E
1
Q
1
G
0
H
3
I
2
L
7
K
0
M
0
F
0
P
2
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 1 N: 2 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 7 M: 0 F: 0 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
28
C134H247N41O36
3008.69
11.93
+8
7.19
-0.171
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
824 µM
Hemolytic Cytotoxic
50% Hemolysis | 824 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin. | Biochim Biophys Acta | 2013
Evidence 2 Activity

Activity

50% Cell death
Toxicity
47 µM
Cytotoxic
50% Cell death | 47 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin. | Biochim Biophys Acta | 2013
Evidence 3 Activity

Activity

50% Cell death
Toxicity
52 µM
Cytotoxic
50% Cell death | 52 | µM | target cell: Human COS-7 cells

Target

Human COS-7 cells

Source & Reference

NA
DBAASP
Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin. | Biochim Biophys Acta | 2013
Evidence 4 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis