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Peptide record

TPDB03413

Antibacterial Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB03413
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
ALWMTLLKKVLKAAAKAALKAVLVGANA
Physicochemical Analysis
C134H235N35O31S1
RDCEQHIFPSY
A
2864.62
11.12
5
0
20
+5
-1.24
1.018
146.79
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
192.00
2
Residue Composition
number
9
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
6
L
5
K
1
M
0
F
0
P
0
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 9 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 5 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
28
C134H235N35O31S1
2864.62
11.12
+5
-1.24
1.018
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
1.2±0.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 1.2±0.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 2 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis