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Peptide record

TPDB03407

Antibacterial Anticancer Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB03407
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
IRPIIRPIIRPIIRPIIRPIIRPIIRPI
Physicochemical Analysis
C161H289N49O29
ANDCEQGHLKMFSTWYV
I
3375.38
13.18
7
0
14
+7
4.48
0.725
195.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
14
I
0
L
0
K
0
M
0
F
7
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 14 L: 0 K: 0 M: 0 F: 0 P: 7 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
28
C161H289N49O29
3375.38
13.18
+7
4.48
0.725
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides with high proteolytic resistance for combating gram-negative bacteria. | J Med Chem | 2019
Evidence 2 Activity

Activity

IC50
Toxicity
324 µM
Cytotoxic
IC50 | 324 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Antimicrobial peptides with high proteolytic resistance for combating gram-negative bacteria. | J Med Chem | 2019
Evidence 3 Activity

Activity

IC50
Toxicity
125.5 µM
Cytotoxic
IC50 | 125.5 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Antimicrobial peptides with high proteolytic resistance for combating gram-negative bacteria. | J Med Chem | 2019