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Peptide record

TPDB03375

A12L Antibacterial Anticancer Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB03375
A12L
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKSFLKTFKSLKKTVLHTALKAISS
Physicochemical Analysis
C142H236N36O34
RNDCEQGMPY
K
2991.66
11.29
8
0
11
+7
1.90
-0.138
93.85
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
183.84
7
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
4
L
7
K
0
M
2
F
0
P
4
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 4 K: 7 M: 0 F: 2 P: 0 S: 4 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
26
C142H236N36O34
2991.66
11.29
+7
1.90
-0.138
Free
L
Linear
Free
Anticancer
PeptideV13K
Evidence Records 12 records
Evidence 1 Activity

Activity

IC50
IC50=11.1 µMo/L
Anticancer
11.1 µM

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT/MTS assay
36-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50=4.3 µMo/L
Anticancer
4.3 µM

Target

Skin Cancer
A-375
Skin

Assay & Model

MTT/MTS assay
36-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 3 Activity

Activity

IC50
IC50=5 µMo/L
Anticancer
5 µM

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT/MTS assay
36-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 4 Activity

Activity

IC50
IC50=6.4 µMo/L
Anticancer
6.4 µM

Target

Colorectal Cancer
SW-1116
Colon

Assay & Model

MTT/MTS assay
36-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 5 Activity

Activity

IC50
IC50=7.5 µMo/L
Anticancer
7.5 µM

Target

Rhabdomyosarcoma Cancer
RD
Muscle

Assay & Model

MTT/MTS assay
36-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 6 Activity

Activity

IC50
IC50=4.4 µMo/L
Anticancer
4.4 µM

Target

Lung Cancer
H-1299
Lung

Assay & Model

MTT/MTS assay
36-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 7 Activity

Activity

IC50
IC50=5.2 µMo/L
Anticancer
5.2 µM

Target

Skin Cancer
B-16
Skin

Assay & Model

MTT/MTS assay
36-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 8 Activity

Activity

IC50
IC50=3.8 µMo/L
Anticancer
3.8 µM

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT/MTS assay
36-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011
Evidence 9 Activity

Activity

MHC
Hemolysis
31.3 µg/mL
[Ref.17158938]MHC=31.3 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Antimicrob Agents Chemother. 2007 Apr 51(4):1398-406.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 10 Activity

Activity

0% Hemolysis
Toxicity
31.3 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 31.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides | Antimicrob Agents Chemother | 2007
Evidence 11 Activity

Activity

MHC
Toxicity
31.3 µg/mL
Hemolytic
Hemolytic_activity: [Ref.17158938]MHC=31.3 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2007 Apr 51(4):1398-406.
Evidence 12 Hemolysis

Activity

31.3 µg/mL
MHC
[Ref.17158938]MHC=31.3 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
Antimicrob Agents Chemother. 2007 Apr 51(4):1398-406.
DRAMP4
PD_Hemolysis