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Peptide record

TPDB03368

Antibacterial Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB03368
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 26-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GILSSFKGVAKGVAKDLAGKLLETLK
Physicochemical Analysis
C121H211N31O34
RNCQHMPWY
LK
2644.19
10.38
5
2
12
+3
4.03
0.373
123.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
3
A
0
R
0
N
1
D
0
C
1
E
0
Q
4
G
0
H
1
I
5
L
5
K
0
M
1
F
0
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 5 K: 5 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
26
C121H211N31O34
2644.19
10.38
+3
4.03
0.373
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designed peptide with a flexible central motif from ranatuerins adapts its conformation to bacterial membranes. | Biochim Biophys Acta | 2018
Evidence 2 Activity

Activity

50% Cell death
Toxicity
60 µM
Cytotoxic
50% Cell death | 60 | µM | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
Designed peptide with a flexible central motif from ranatuerins adapts its conformation to bacterial membranes. | Biochim Biophys Acta | 2018