TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB03344

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

HKMDLHWYLRTLEEVVIRALQRFQFR

FASTA

>TPDB03344|Antibacterial;Antifungal|length=26
HKMDLHWYLRTLEEVVIRALQRFQFR

Formula C156H242N46O37S1

Absent Amino Acids NCGPS

Common Amino Acids RL

Mass 3385.98

PI 10.40

Basic Residues 7

Acidic Residues 3

Hydrophobic Residues 13

Net Charge +2

Boman Index 4.86

Hydrophobicity -0.435

Aliphatic Index 101.15

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 206.44

Polar Residues 4

number

1

A

4

R

0

N

1

D

0

C

2

E

2

Q

0

G

2

H

1

I

4

L

1

K

1

M

2

F

0

P

0

S

1

T

1

W

1

Y

2

V

Amino Acid Distribution

A: 1 R: 4 N: 0 D: 1 C: 0 E: 2 Q: 2 G: 0 H: 2 I: 1 L: 4 K: 1 M: 1 F: 2 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 2

Length

26

Formula

C156H242N46O37S1

Mass

3385.98

PI

10.40

Net Charge

+2

Boman Index

4.86

Hydrophobicity

-0.435

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

It inhibited the in vitro growth of X. axonopodis pv. glycines, the causative agent of the bacterial pustule disease, at 10 uM. Also active ex vivo and in vivo after vector transformation. It remains to be confirmed whether this AMP (exact region?) is expressed to protect soybeans from infection.

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

It inhibited the in vitro growth of X. axonopodis pv. glycines, the causative agent of the bacterial pustule disease, at 10 uM. Also active ex vivo and in vivo after vector transformation. It remains to be confirmed whether this AMP (exact region?) is expressed to protect soybeans from infection.