TPDB

3D PDB MODEL

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TPDB ID TPDB03308

Activity

Antibacterial Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.

Sequence

KKLFKKILKYLTTGLPALISWKDEL

FASTA

>TPDB03308|Antibacterial;Hemolysis;Toxicity|length=25
KKLFKKILKYLTTGLPALISWKDEL

Formula C143H236N32O34

Absent Amino Acids RNCQHMV

Common Amino Acids LK

Mass 2947.64

PI 10.36

Basic Residues 6

Acidic Residues 2

Hydrophobic Residues 12

Net Charge +4

Boman Index 1.99

Hydrophobicity -0.016

Aliphatic Index 128.80

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 6990

Absorbance 280nm 237.14

Polar Residues 4

number

1

A

0

R

0

N

1

D

0

C

1

E

0

Q

1

G

0

H

2

I

6

L

6

K

0

M

1

F

1

P

1

S

2

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 2 L: 6 K: 6 M: 0 F: 1 P: 1 S: 1 T: 2 W: 1 Y: 1 V: 0

Length

25

Formula

C143H236N32O34

Mass

2947.64

PI

10.36

Net Charge

+4

Boman Index

1.99

Hydrophobicity

-0.016

Evidence 1 Activity

Activity

Activity Endpoint 14% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

14% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Derivatives of the antimicrobial peptide BP100 for expression in plant systems. | PLoS One | 2013

Evidence 2 Activity

Activity

Activity Endpoint 49% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

49% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Derivatives of the antimicrobial peptide BP100 for expression in plant systems. | PLoS One | 2013

Evidence 3 Activity

Activity

Activity Endpoint 63% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 250 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

63% Hemolysis | 250 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Derivatives of the antimicrobial peptide BP100 for expression in plant systems. | PLoS One | 2013

Evidence 4 Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Database Source PD_Hemolysis