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Peptide record

TPDB03255

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB03255
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
GIRDVLKGAAKAFVKTVAGHIAN
Physicochemical Analysis
C105H178N32O28
CEQMPSWY
A
2336.77
10.83
5
1
12
+3
3.61
0.387
110.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
5
A
1
R
1
N
1
D
0
C
0
E
0
Q
3
G
1
H
2
I
1
L
3
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 2 L: 1 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
23
C105H178N32O28
2336.77
10.83
+3
3.61
0.387
Evidence Records 2 records
Evidence 1 Activity

Activity

25% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
25% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Computational design of highly selective antimicrobial peptides. | J Chem Inf Model | 2009
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
25 %
Hemolytic
Hemolytic_activity: [Ref.19947578]25% hemolysis against human erythrocytes at 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Chem Inf Model. 2009 Dec 49(12):2873-82.