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Peptide record

TPDB03249

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB03249
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP dbAMP 3.0 PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FWGTLAKWALKAIPAAMGMKQNK
Physicochemical Analysis
C120H189N31O27S2
RDCEHSYV
A
2562.13
11.00
4
0
13
+4
-2.00
0.009
72.61
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
429.33
3
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
0
E
1
Q
2
G
0
H
1
I
2
L
4
K
2
M
1
F
1
P
0
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 2 K: 4 M: 2 F: 1 P: 1 S: 0 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
23
C120H189N31O27S2
2562.13
11.00
+4
-2.00
0.009
Evidence Records 5 records
Evidence 1 Activity

Activity

4.2% Hemolysis
Toxicity
2.5 µM
Hemolytic Cytotoxic
4.2% Hemolysis | 2.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant Ant Dinoponera quadriceps and Synergistic Effects with Antimycotic Drugs. | Antibiotics (Basel) | 2020
Evidence 2 Activity

Activity

26.2% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
26.2% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant Ant Dinoponera quadriceps and Synergistic Effects with Antimycotic Drugs. | Antibiotics (Basel) | 2020
Evidence 3 Activity

Activity

57.9% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
57.9% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant Ant Dinoponera quadriceps and Synergistic Effects with Antimycotic Drugs. | Antibiotics (Basel) | 2020
Evidence 4 Activity

Activity

50% Cell death
Toxicity
25.7±2 µM
Cytotoxic
50% Cell death | 25.7±2 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
The dinoponeratoxin peptides from the giant ant Dinoponera quadriceps display in vitro antitrypanosomal activity. | Biol Chem | 2018
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis