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Peptide record

TPDB03221

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB03221
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, and Peptipedia, with an available 3D structural model.
Sequence
EEEEAAAGWGLRRLLKYGKRS
Physicochemical Analysis
C106H171N33O32
NDCQHIMFPTV
E
2419.73
9.65
5
4
8
+1
7.67
-1.081
70.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
6990
288.88
2
Residue Composition
number
3
A
3
R
0
N
0
D
0
C
4
E
0
Q
3
G
0
H
0
I
3
L
2
K
0
M
0
F
0
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 0 D: 0 C: 0 E: 4 Q: 0 G: 3 H: 0 I: 0 L: 3 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
21
C106H171N33O32
2419.73
9.65
+1
7.67
-1.081
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Toxicity
>300 µM
Cytotoxic
IC50 | >300 | µM | target cell: Cystic fibrosis bronchial epithelial cells CFBE41o-

Target

Cystic fibrosis bronchial epithelial cells CFBE41o-

Source & Reference

NA
DBAASP
Differential In Vitro and In Vivo Toxicities of Antimicrobial Peptide Prodrugs for Potential Use in Cystic Fibrosis. | Antimicrob Agents Chemother | 2016