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Peptide record

TPDB03214

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB03214
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IHRDQQHESFLDARPEPGLTE
Physicochemical Analysis
C106H163N33O36
NCKMWYV
E
2475.66
4.67
4
5
5
-3
11.67
-1.348
60.48
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
4
Residue Composition
number
1
A
2
R
0
N
2
D
0
C
3
E
2
Q
1
G
2
H
1
I
2
L
0
K
0
M
1
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 2 C: 0 E: 3 Q: 2 G: 1 H: 2 I: 1 L: 2 K: 0 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C106H163N33O36
2475.66
4.67
-3
11.67
-1.348
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0.7 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 0.7% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.