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Peptide record

TPDB03210

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB03210
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GFCWYVCVYRNGVRVCYRRCN
Physicochemical Analysis
C115H170N36O27S4
ADEQHILKMPST
RCV
2617.08
9.14
4
0
9
+4
-2.38
-0.048
55.24
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
10220
390.51
9
Residue Composition
number
0
A
4
R
2
N
0
D
4
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
3
Y
4
V
Amino Acid Distribution
A: 0 R: 4 N: 2 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 3 V: 4
Chemical Descriptors
21
C115H170N36O27S4
2617.08
9.14
+4
-2.38
-0.048
Evidence Records 8 records
Evidence 1 Activity

Activity

4.4±1.1% Hemolysis
Toxicity
300 µg/mL
Hemolytic Cytotoxic
4.4±1.1% Hemolysis | 300 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides. | ACS Infect Dis | 2016
Evidence 2 Activity

Activity

50% Cell death
Toxicity
271 µg/mL
Cytotoxic
50% Cell death | 271 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. | Nat Commun | 2020
Evidence 3 Activity

Activity

50% Cell death
Toxicity
170 µg/mL
Cytotoxic
50% Cell death | 170 | µg/mL | target cell: Human kidney proximal tubule HK-2 cells

Target

Human kidney proximal tubule HK-2 cells

Source & Reference

NA
DBAASP
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. | Nat Commun | 2020
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
204 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 204 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. | Nat Commun | 2020
Evidence 5 Activity

Activity

20% Hemolysis
Toxicity
1.2 ± 1 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 1.2 ± 1 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigations into the membrane activity of arenicin antimicrobial peptide AA139. | Biochim Biophys Acta | 2022
Evidence 6 Activity

Activity

50% Cytotoxicity
Toxicity
104.6 ± 1.8 µg/mL
Cytotoxic
50% Cytotoxicity | 104.6 ± 1.8 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Investigations into the membrane activity of arenicin antimicrobial peptide AA139. | Biochim Biophys Acta | 2022
Evidence 7 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Human bronchial epithelial cells BEAS-2B

Target

Human bronchial epithelial cells BEAS-2B

Source & Reference

NA
DBAASP
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus | J Biomed Sci | 2024
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus | J Biomed Sci | 2024