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Peptide record

TPDB03197

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03197
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RLVRILVSKRPVAIKPYFRL
Physicochemical Analysis
C115H198N34O23
NDCEQGHMTW
R
2425.05
12.41
6
0
11
+6
1.92
0.325
146.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
61.44
2
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
3
L
2
K
0
M
1
F
2
P
1
S
0
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 3 K: 2 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 1 V: 3
Chemical Descriptors
20
C115H198N34O23
2425.05
12.41
+6
1.92
0.325
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
<5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
4.0 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 4.0% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.