Back to search

Peptide record

TPDB03196

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB03196
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
IVPFLLGMVPKLVCLITKKC
Physicochemical Analysis
C105H183N23O22S3
ARNDEQHSWY
L
2215.93
9.80
3
0
11
+3
-0.47
1.525
160.50
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
125
5.64
3
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
2
I
4
L
3
K
1
M
1
F
2
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 4 K: 3 M: 1 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
20
C105H183N23O22S3
2215.93
9.80
+3
-0.47
1.525
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. epidermidis, E. coli, and C. parapsilosis. It stimulated the release of insulin from BRIN-BD11 clonal ?-cells at concentrations ?1 nM.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. epidermidis, E. coli, and C. parapsilosis. It stimulated the release of insulin from BRIN-BD11 clonal ?-cells at concentrations ?1 nM.
Evidence 3 Activity

Activity

LC50
Hemolysis
7 µM
mouse erythrocytes: LC50=7 µM

Target

mouse erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Pept Sci. 2017 Oct 23(10):769-776.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
7 µM
Hemolytic Cytotoxic
50% Hemolysis | 7 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae). | J Pept Sci | 2017
Evidence 5 Activity

Activity

LC50
Toxicity
7 µM
Hemolytic Cytotoxic
Hemolytic_activity: mouse erythrocytes: LC50=7 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2017 Oct 23(10):769-776.
Evidence 6 Hemolysis

Activity

7 µM
LC50
mouse erythrocytes: LC50=7 µM
Hemolysis

Target

mouse erythrocytes

Source & Reference

APD_complete PD_Hemolysis
J Pept Sci. 2017 Oct 23(10):769-776.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.