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Peptide record

TPDB03194

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03194
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
TTSIRRRYQVSLIRRHRGKR
Physicochemical Analysis
C107H191N45O27
ANDCEMFPW
R
2539.98
12.80
9
0
5
+8
6.70
-1.490
73.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
58.66
6
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
1
Q
1
G
1
H
2
I
1
L
1
K
0
M
0
F
0
P
2
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 2 L: 1 K: 1 M: 0 F: 0 P: 0 S: 2 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
20
C107H191N45O27
2539.98
12.80
+8
6.70
-1.490
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
<5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
3.1 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 3.1% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.