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Peptide record

TPDB03193

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03193
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SMLAYVDKNDHINPPHSPRS
Physicochemical Analysis
C98H152N30O31S1
CEQGFTW
PS
2278.53
7.90
4
2
6
+0
6.62
-1.055
58.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
65.39
6
Residue Composition
number
1
A
1
R
2
N
2
D
0
C
0
E
0
Q
0
G
2
H
1
I
1
L
1
K
1
M
0
F
3
P
3
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 2 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 1 K: 1 M: 1 F: 0 P: 3 S: 3 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
20
C98H152N30O31S1
2278.53
7.90
+0
6.62
-1.055
Evidence Records 2 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
1.5 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 1.5% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.