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Peptide record

TPDB03178

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03178
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
CNPLNGADRRTDSFPRFTVI
Physicochemical Analysis
C98H155N31O30S1
EQHKMWY
R
2279.56
9.01
3
2
6
+1
3.58
-0.545
58.50
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
6
Residue Composition
number
1
A
3
R
2
N
2
D
1
C
0
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
2
F
2
P
1
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 2 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 2 P: 2 S: 1 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C98H155N31O30S1
2279.56
9.01
+1
3.58
-0.545
Evidence Records 2 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
1.7 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 1.7% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.