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Peptide record

TPDB03175

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03175
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
DATPHAALFFTVKDHTAGDN
Physicochemical Analysis
C94H138N26O31
RCEQIMSWY
A
2128.29
5.03
3
3
8
-2
4.47
-0.380
54.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
4
Residue Composition
number
4
A
0
R
1
N
3
D
0
C
0
E
0
Q
1
G
2
H
0
I
1
L
1
K
0
M
2
F
1
P
0
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 3 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 1 K: 1 M: 0 F: 2 P: 1 S: 0 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C94H138N26O31
2128.29
5.03
-2
4.47
-0.380
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0.6 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 0.6% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.