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Peptide record

TPDB03171

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03171
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
YYNPLPHDCGRDNNTDICSR
Physicochemical Analysis
C97H145N31O34S2
AEQKMFWV
ND
2353.53
5.19
3
3
4
-1
5.48
-1.380
39.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
3105
131.93
9
Residue Composition
number
0
A
2
R
3
N
3
D
2
C
0
E
0
Q
1
G
1
H
1
I
1
L
0
K
0
M
0
F
2
P
1
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 3 D: 3 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 1 K: 0 M: 0 F: 0 P: 2 S: 1 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
20
C97H145N31O34S2
2353.53
5.19
-1
5.48
-1.380
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
1.1 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 1.1% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.