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Peptide record

TPDB03170

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03170
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
YDLSDSNCLPANRDKRYYVI
Physicochemical Analysis
C105H161N29O34S1
EQGHMFTW
DY
2405.67
6.32
3
3
8
-0
3.26
-0.845
78.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
4470
185.81
8
Residue Composition
number
1
A
2
R
2
N
3
D
1
C
0
E
0
Q
0
G
0
H
1
I
2
L
1
K
0
M
0
F
1
P
2
S
0
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 3 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 1 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 3 V: 1
Chemical Descriptors
20
C105H161N29O34S1
2405.67
6.32
-0
3.26
-0.845
Evidence Records 2 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
3.1 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 3.1% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.