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Peptide record

TPDB03167

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03167
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SNGDGTLDAGSTCAPFYARA
Physicochemical Analysis
C82H124N24O31S1
EQHIKMWV
A
1974.09
3.88
1
2
7
-1
1.16
-0.290
39.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
75.48
7
Residue Composition
number
4
A
1
R
1
N
2
D
1
C
0
E
0
Q
3
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
2
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 2 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 2 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
20
C82H124N24O31S1
1974.09
3.88
-1
1.16
-0.290
Evidence Records 2 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
1.8 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 1.8% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.