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Peptide record

TPDB03166

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03166
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SDDAQRCYPHNRTPFTYTYI
Physicochemical Analysis
C108H154N30O34S1
EGLKMWV
TY
2448.65
7.15
3
2
6
+0
2.82
-1.230
24.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
4470
182.55
10
Residue Composition
number
1
A
2
R
1
N
2
D
1
C
0
E
1
Q
0
G
1
H
1
I
0
L
0
K
0
M
1
F
2
P
1
S
3
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 2 C: 1 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 1 P: 2 S: 1 T: 3 W: 0 Y: 3 V: 0
Chemical Descriptors
20
C108H154N30O34S1
2448.65
7.15
+0
2.82
-1.230
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
3.3 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 3.3% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.