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Peptide record

TPDB03163

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03163
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
PCNPDHDYRPFGNFRIAFTT
Physicochemical Analysis
C107H150N30O30S1
EQLKMSWV
FP
2368.61
7.15
3
2
6
+0
2.47
-0.845
24.50
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
62.91
6
Residue Composition
number
1
A
2
R
2
N
2
D
1
C
0
E
0
Q
1
G
1
H
1
I
0
L
0
K
0
M
3
F
3
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 2 C: 1 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 0 K: 0 M: 0 F: 3 P: 3 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
20
C107H150N30O30S1
2368.61
7.15
+0
2.47
-0.845
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 0% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.