Back to search

Peptide record

TPDB03154

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB03154
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LSVDKRPVLHPEHIYGHNHY
Physicochemical Analysis
C110H163N33O29
ACQMFTW
H
2411.71
8.00
6
2
7
+0
7.18
-0.910
87.50
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
2980
123.56
4
Residue Composition
number
0
A
1
R
1
N
1
D
0
C
1
E
0
Q
1
G
4
H
1
I
2
L
1
K
0
M
0
F
2
P
1
S
0
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 4 I: 1 L: 2 K: 1 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 2 V: 2
Chemical Descriptors
20
C110H163N33O29
2411.71
8.00
+0
7.18
-0.910
Evidence Records 2 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
3.1 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 3.1% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.