Back to search

Peptide record

TPDB03153

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB03153
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LPLPSCSSHGGDADNTSQRN
Physicochemical Analysis
C81H130N28O33S1
EIKMFWYV
S
2056.15
5.10
2
2
3
-1
5.70
-1.060
44.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
9
Residue Composition
number
1
A
1
R
2
N
2
D
1
C
0
E
1
Q
2
G
1
H
0
I
2
L
0
K
0
M
0
F
2
P
4
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 2 C: 1 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 2 K: 0 M: 0 F: 0 P: 2 S: 4 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C81H130N28O33S1
2056.15
5.10
-1
5.70
-1.060
Evidence Records 2 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
2.6 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 2.6% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.