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Peptide record

TPDB03152

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB03152
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KVLKAAAKAALNAVLVGANA
Physicochemical Analysis
C85H153N25O23
RDCEQHIMFPSTWY
A
1893.30
10.84
3
0
14
+3
0.99
0.965
142.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
8
A
0
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 8 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
20
C85H153N25O23
1893.30
10.84
+3
0.99
0.965
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
24±1 µM
Hemolytic Cytotoxic
50% Hemolysis | 24±1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
50% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives | J Biol Chem | 2002
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis