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Peptide record

TPDB03109

Antibacterial Antifungal Neurotoxin Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB03109
Antibacterial Antifungal Neurotoxin Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept NTxPred2 ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Antifungal, Neurotoxin, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ARDGYIVDEKGCKFACFIN
Physicochemical Analysis
C95H145N25O28S2
QHLMPSTW
ADCGIKF
2149.47
6.26
3
3
8
-0
3.14
-0.053
66.84
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1615
75.13
4
Residue Composition
number
2
A
1
R
1
N
2
D
2
C
1
E
0
Q
2
G
0
H
2
I
0
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 2 C: 2 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
19
C95H145N25O28S2
2149.47
6.26
-0
3.14
-0.053
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

Active against K. pneumoniae (MIC 64 uM). Also active in neurons.
Evidence 2 Activity

Activity

MIC
Antifungal
64 µM

Target

Klebsiella pneumoniae

Source & Reference

Antifungipept

Other

Active against K. pneumoniae (MIC 64 uM). Also active in neurons.
Evidence 3 Activity

Activity

Neurotoxin
FUNCTION: May block sodium channels (Nav) found (By similarity). Reversibly modifies the firing of DRG neurons by causing membrane depolarization and increasing the number of action potentials (PubMed:25633390). Shows antimicrobial activity against the Gram-negative bacteria K.pneumoniae (MIC=64 uM), and only a very weak activity against S.aureus (PubMed:25633390). Does not show hemolytic activity (PubMed:25633390). {ECO:0000250|UniProtKB:P58296, ECO:0000269|PubMed:25633390}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides margaritatus (Central American bark Scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
May block sodium channels (Nav) found (By similarity). Reversibly modifies the firing of DRG neurons by causing membrane depolarization and increasing the number of action potentials (PubMed:25633390).
Toxin Cm38
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Evidence at protein level
Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25633390}.
Additional Detail Fields 7 fields
Antibiotic Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family
Toxin Cm38
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25633390}.
scorpion