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Peptide record

TPDB03022

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB03022
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
TRDTNDLISSRTAAPSMV
Physicochemical Analysis
C78H135N25O30S1
CEQGHKFWY
ST
1935.14
6.93
2
2
6
-0
4.39
-0.422
70.56
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
7
Residue Composition
number
2
A
2
R
1
N
2
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
0
K
1
M
0
F
1
P
3
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 2 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 0 M: 1 F: 0 P: 1 S: 3 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C78H135N25O30S1
1935.14
6.93
-0
4.39
-0.422
Evidence Records 2 records
Evidence 1 Activity

Activity

8% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
8% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
8.4 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 8.4% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.