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Peptide record

TPDB03015

Antibacterial Antifungal Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB03015
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
HLNKRVQRELIGWLRWLK
Physicochemical Analysis
C109H177N35O23
ADCMFPSTY
L
2345.83
12.13
6
1
8
+4
2.22
-0.739
124.44
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
11000
468.92
2
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
1
E
1
Q
1
G
1
H
1
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 1 I: 1 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
18
C109H177N35O23
2345.83
12.13
+4
2.22
-0.739
Evidence Records 3 records
Evidence 1 Activity

Activity

4% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
4% Hemolysis | 100 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from ?-amylase of rice. | Biopolymers | 2016
Evidence 2 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-18 and its amino acid-substituted analogs. | J Biosci Bioeng | 2016
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
2 %
Hemolytic
Hemolytic_activity: [Ref.27478151] 2% hemolysis at 50 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biosci Bioeng. 2016 Dec 122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008. ##Biopolymers. 2016 Mar 106(2):219-229. doi: 10.1002/bip.22820.