TPDB

3D PDB MODEL

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TPDB ID TPDB02996

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GALRGCWTKSYPPKPCK

FASTA

>TPDB02996|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=17
GALRGCWTKSYPPKPCK

Formula C85H134N24O21S2

Absent Amino Acids NDEQHIMFV

Common Amino Acids KP

Mass 1892.27

PI 10.08

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +4

Boman Index 1.42

Hydrophobicity -0.876

Aliphatic Index 28.82

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 376.00

Polar Residues 5

number

1

A

1

R

0

N

0

D

2

C

0

E

0

Q

2

G

0

H

0

I

1

L

3

K

0

M

0

F

3

P

1

S

1

T

1

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 3 M: 0 F: 0 P: 3 S: 1 T: 1 W: 1 Y: 1 V: 0

Length

17

Formula

C85H134N24O21S2

Mass

1892.27

PI

10.08

Net Charge

+4

Boman Index

1.42

Hydrophobicity

-0.876

Evidence 1 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 20 %

Hemolysis Raw

[Ref.14636071] It has 20% hemolytic activity at 100 µM against human erythrocytes

Target

RBC Target human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete APD_hemolytic PD_Hemolysis

Source DRAMP4

Reference

Biochemistry. 2003 Dec 2 42(47):14023-14035.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity. | Biochemistry | 2003

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.14636071] It has 20% hemolytic activity at 100 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochemistry. 2003 Dec 2 42(47):14023-14035.

Evidence 4 Hemolysis

Activity

Activity Measurement 20 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.14636071] It has 20% hemolytic activity at 100 µM against human erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Reference

Biochemistry. 2003 Dec 2 42(47):14023-14035.

Source DRAMP4

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.