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Peptide record

TPDB02990

Antibacterial Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB02990
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KKKKKKALFALWLAFLA
Physicochemical Analysis
C101H166N24O18
RNDCEQGHIMPSTYV
K
2004.58
11.21
6
0
11
+6
-1.09
0.218
115.29
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
274.37
0
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
6
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 6 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C101H166N24O18
2004.58
11.21
+6
-1.09
0.218
Evidence Records 11 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
33 %
[Ref.31194548] 33% (± 22) hemolysis at 40µM against human blood cells.

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

25% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
25% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions. | J Biol Chem | 2012
Evidence 3 Activity

Activity

26% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
26% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions. | J Biol Chem | 2012
Evidence 4 Activity

Activity

36% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
36% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions. | J Biol Chem | 2012
Evidence 5 Activity

Activity

46% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
46% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions. | J Biol Chem | 2012
Evidence 6 Activity

Activity

41% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
41% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions. | J Biol Chem | 2012
Evidence 7 Activity

Activity

38% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
38% Hemolysis | 160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions. | J Biol Chem | 2012
Evidence 8 Activity

Activity

35% Hemolysis
Toxicity
320 µM
Hemolytic Cytotoxic
35% Hemolysis | 320 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Roles of hydrophobicity and charge distribution of cationic antimicrobial peptides in peptide-membrane interactions. | J Biol Chem | 2012
Evidence 9 Activity

Activity

33±22% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
33±22% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability. | J Med Chem | 2019
Evidence 10 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.31194548] 33% (± 22) hemolysis at 40µM against human blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.
Evidence 11 Hemolysis

Activity

33 %
% Hemolysis
[Ref.31194548] 33% (± 22) hemolysis at 40µM against human blood cells.
Hemolysis

Source & Reference

HemoPI PD_Hemolysis
J Med Chem. 2019 Jul 1. doi: 10.1021/acs.jmedchem.9b00657.
DRAMP4
PD_Hemolysis