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Peptide record

TPDB02912

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB02912
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
EPCSPKNNYHDLFYRT
Physicochemical Analysis
C88H126N24O27S1
AQGIMWV
NPY
1984.17
7.15
3
2
4
+0
4.21
-1.487
24.38
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
2980
150.19
7
Residue Composition
number
0
A
1
R
2
N
1
D
1
C
1
E
0
Q
0
G
1
H
0
I
1
L
1
K
0
M
1
F
2
P
1
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 1 C: 1 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 1 M: 0 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
16
C88H126N24O27S1
1984.17
7.15
+0
4.21
-1.487
Evidence Records 2 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. | Cell | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
1.7 %
Hemolytic
Hemolytic_activity: [Ref.29307492] The peptide showed 1.7% hemolysis against human red blood cells at 50 µM. PBS was uesd as a negative control and 1% triton was used as a positive control for 100% lysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell. 2018 Jan 25 172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4.