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Peptide record

TPDB02899

Antibacterial Antiviral Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB02899
Antibacterial Antiviral Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AI4AVP dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antiviral, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.
Sequence
ALWMTLLKKVLKAAAK
Physicochemical Analysis
C85H149N21O18S1
RNDCEQGHIFPSY
ALK
1785.31
11.00
4
0
11
+4
-0.83
0.706
140.62
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
308.07
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
4
K
1
M
0
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 4 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
16
C85H149N21O18S1
1785.31
11.00
+4
-0.83
0.706
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
23±1 µM
Hemolytic Cytotoxic
50% Hemolysis | 23±1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 2 Activity

Activity

10% Cytotoxicity
Toxicity
10 µM
Cytotoxic
10% Cytotoxicity | 10 | µM | target cell: Baby Hamster Kidney cells BHK-21 BSR

Target

Baby Hamster Kidney cells BHK-21 BSR

Source & Reference

NA
DBAASP
Dermaseptins as Potential Antirabies Compounds | Vaccine | 2019
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis