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Peptide record

TPDB02841

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB02841
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WLRRIKAWLRRKRK
Physicochemical Analysis
C91H156N34O15
NDCEQGHMFPSTYV
R
1966.46
13.01
8
0
6
+8
1.72
-1.579
90.71
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
559.38
0
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
3
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
14
C91H156N34O15
1966.46
13.01
+8
1.72
-1.579
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
128 µM
Cytotoxic
EC50 | 128 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. | Sci Rep | 2017
Evidence 2 Activity

Activity

EC50
Toxicity
128 µM
Cytotoxic
EC50 | 128 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. | Sci Rep | 2017
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
50% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. | Sci Rep | 2017