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Peptide record

TPDB02819

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB02819
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 SATPdb dbACP Antifungipept CAFPdb DRAVP 2.0 CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
INLKALAALAKKIL
Physicochemical Analysis
C70H130N18O16
RDCEQGHMFPSTWYV
AL
1479.91
10.84
3
0
10
+3
-0.15
1.157
195.71
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
4
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C70H130N18O16
1479.91
10.84
+3
-0.15
1.157
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
10-20 µM

Target

Staphylococcus aureus ATCC 29213 or MRSA

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
t 18 (4), 383-7), B. subtilis ATCC6633 (MIC ~20 uM), E. faecalis ATCC 12953 (MIC ~10 uM), S. aureus ATCC 29213 or MRSA (MIC 10-20 uM), S. pyogenes (MIC ~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeru
Evidence 2 Activity

Activity

MIC
Antibacterial
10-30 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

2953 (MIC ~10 uM), S. aureus ATCC 29213 or MRSA (MIC 10-20 uM), S. pyogenes (MIC ~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeruginosa 10-20 uM), S. enterica (MIC 10-20 uM) ( Sil
Evidence 3 Activity

Activity

MIC
Antibacterial
10-20 µM

Target

S. enterica

Source & Reference

dbAMP DRAMP

Other

~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeruginosa 10-20 uM), S. enterica (MIC 10-20 uM) ( Silva et al., 2020 ).
Evidence 4 Activity

Activity

MIC
Antifungal
10-20 µM

Target

Staphylococcus aureus ATCC 29213 or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
t 18 (4), 383-7), B. subtilis ATCC6633 (MIC ~20 uM), E. faecalis ATCC 12953 (MIC ~10 uM), S. aureus ATCC 29213 or MRSA (MIC 10-20 uM), S. pyogenes (MIC ~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeru
Evidence 5 Activity

Activity

MIC
Antifungal
10-30 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2953 (MIC ~10 uM), S. aureus ATCC 29213 or MRSA (MIC 10-20 uM), S. pyogenes (MIC ~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeruginosa 10-20 uM), S. enterica (MIC 10-20 uM) ( Sil
Evidence 6 Activity

Activity

MIC
Antifungal
10-20 µM

Target

S. enterica

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeruginosa 10-20 uM), S. enterica (MIC 10-20 uM) ( Silva et al., 2020 ).
Evidence 7 Activity

Activity

MIC
Antiparasitic
10-20 µM

Target

Staphylococcus aureus ATCC 29213 or MRSA

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
t 18 (4), 383-7), B. subtilis ATCC6633 (MIC ~20 uM), E. faecalis ATCC 12953 (MIC ~10 uM), S. aureus ATCC 29213 or MRSA (MIC 10-20 uM), S. pyogenes (MIC ~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeru
Evidence 8 Activity

Activity

MIC
Antiparasitic
10-30 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

2953 (MIC ~10 uM), S. aureus ATCC 29213 or MRSA (MIC 10-20 uM), S. pyogenes (MIC ~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeruginosa 10-20 uM), S. enterica (MIC 10-20 uM) ( Sil
Evidence 9 Activity

Activity

MIC
Antiparasitic
10-20 µM

Target

S. enterica

Source & Reference

DRAMP

Other

~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeruginosa 10-20 uM), S. enterica (MIC 10-20 uM) ( Silva et al., 2020 ).
Evidence 10 Activity

Activity

MIC
Antiviral
10-20 µM

Target

Staphylococcus aureus ATCC 29213 or MRSA

Source & Reference

DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
t 18 (4), 383-7), B. subtilis ATCC6633 (MIC ~20 uM), E. faecalis ATCC 12953 (MIC ~10 uM), S. aureus ATCC 29213 or MRSA (MIC 10-20 uM), S. pyogenes (MIC ~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeru
Evidence 11 Activity

Activity

MIC
Antiviral
10-30 µM

Target

Escherichia coli

Source & Reference

DRAMP DRAVP 2.0

Other

2953 (MIC ~10 uM), S. aureus ATCC 29213 or MRSA (MIC 10-20 uM), S. pyogenes (MIC ~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeruginosa 10-20 uM), S. enterica (MIC 10-20 uM) ( Sil
Evidence 12 Activity

Activity

MIC
Antiviral
10-20 µM

Target

S. enterica

Source & Reference

DRAMP DRAVP 2.0

Other

~10 uM), E. coli (MIC 10-30 uM), K. pneumoniae (MIC 10-20 ~uM), P. aeruginosa 10-20 uM), S. enterica (MIC 10-20 uM) ( Silva et al., 2020 ).
Evidence 13 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern Africa. | Eur J Biochem | 2002
Evidence 14 Activity

Activity

50% Cell death
Toxicity
12.5 µM
Cytotoxic
50% Cell death | 12.5 | µM | target cell: Mouse fibroblasts 3T3-L1

Target

Mouse fibroblasts 3T3-L1

Source & Reference

NA
DBAASP
Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants With Extended Antibacterial Properties | J Med Chem | 2019
Evidence 15 Activity

Activity

50% Cell death
Toxicity
50 µM
Cytotoxic
50% Cell death | 50 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants With Extended Antibacterial Properties | J Med Chem | 2019
Evidence 16 Activity

Activity

45% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
45% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants With Extended Antibacterial Properties | J Med Chem | 2019
Evidence 17 Activity

Activity

<5% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
<5% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of hydrophobicity on the antimicrobial activity of helical antimicrobial peptides: a study focusing on three mastoparans. | Mol Divers | 2024
Evidence 18 Activity

Activity

28% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
28% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of hydrophobicity on the antimicrobial activity of helical antimicrobial peptides: a study focusing on three mastoparans. | Mol Divers | 2024
Evidence 19 Activity

Activity

% Hemolysis
Toxicity
40 %
Hemolytic
Hemolytic_activity: [Ref.27423268]40% hemolysis at 10µM against rat red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2016 Nov 1858(11):2699-2708.
Evidence 20 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.