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Peptide record

TPDB02762

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB02762
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
FLKLLKKLAAKFL
Physicochemical Analysis
C78H133N17O14
RNDCEQGHIMPSTWYV
L
1533.02
11.00
4
0
9
+4
-1.44
0.969
165.38
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
4
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C78H133N17O14
1533.02
11.00
+4
-1.44
0.969
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
15.11±0.85 µg/mL
Cytotoxic
IC50 | 15.11±0.85 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines. | Peptides | 2003
Evidence 2 Activity

Activity

IC50
Toxicity
14.00
Hemolytic Cytotoxic
Hemolytic_activity: Human RBCs: less than 6% hemolysis at 100 µg/ml | Cytotoxicity: HEK293: IC50=14.00 ± 1.46 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2003 Jul 24(7):945-53.