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Peptide record

TPDB02738

Antibacterial Anticancer Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB02738
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
VKKFAWWWAFLKK
Physicochemical Analysis
C92H128N20O14
RNDCEQGHIMPSTY
K
1738.15
11.00
4
0
9
+4
-4.68
-0.085
67.69
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
16500
949.28
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
4
K
0
M
2
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
13
C92H128N20O14
1738.15
11.00
+4
-4.68
-0.085
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
Hemolysis
65 µM
RBC: IC50 ≥ 65 µM

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

IC50
Toxicity
27.6 µM
Cytotoxic
IC50 | 27.6 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>=65 µM
Hemolytic Cytotoxic
50% Hemolysis | >=65 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
65 µM
Hemolytic Cytotoxic
Hemolytic_activity: RBC: IC50 ≥ 65 µM | Cytotoxicity: PBMC: IC50=27.6 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.
Evidence 5 Hemolysis

Activity

65 µM
IC50
RBC: IC50 ≥ 65 µM
Hemolysis

Source & Reference

PD_Hemolysis
Biochim Biophys Acta Biomembr. 2020 Aug 1 1862(8):183228.
DRAMP4
PD_Hemolysis