Back to search

Peptide record

TPDB02728

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB02728
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IRRWRLHWFRRAI
Physicochemical Analysis
C88H136N32O14
NDCEQGKMPSTYV
R
1866.25
13.00
6
0
7
+5
-1.17
-0.777
97.69
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
11000
589.42
0
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
2
I
1
L
0
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
13
C88H136N32O14
1866.25
13.00
+5
-1.17
-0.777
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 2 Activity

Activity

19% Killing
Toxicity
100 µg/mL
Cytotoxic
19% Killing | 100 | µg/mL | target cell: Mouse epithelial Hepa 1-6 cells

Target

Mouse epithelial Hepa 1-6 cells

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31163671] 10% hemolysis at >100 µg/mL against human blood cells. | Cytotoxicity: [Ref.31163671] The cell viability of Hepa 1-6 induced by SP11 is 95.3%, 109.5%, 108.1%, 89.2%, 112.8% and 81.1% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
Pharmaceuticals (Basel). 2019 Jun 3 12(2). pii: E82. doi: 10.3390/ph12020082.