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Peptide record

TPDB02714

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB02714
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KVWSRLRKIFSTR
Physicochemical Analysis
C77H129N25O17
ANDCEQGHMPY
R
1677.03
12.71
5
0
5
+5
1.03
-0.708
82.31
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
327.96
3
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
2
K
0
M
1
F
0
P
2
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C77H129N25O17
1677.03
12.71
+5
1.03
-0.708
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
50-100 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 50-100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 2 Activity

Activity

21% Killing
Toxicity
100 µg/mL
Cytotoxic
21% Killing | 100 | µg/mL | target cell: Mouse epithelial Hepa 1-6 cells

Target

Mouse epithelial Hepa 1-6 cells

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse epithelial Hepa 1-6 cells

Target

Mouse epithelial Hepa 1-6 cells

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31163671] 10% hemolysis at 50–100 µg/mL against human blood cells. | Cytotoxicity: [Ref.31163671] The cell viability of Hepa 1-6 induced by SP9 is 104.7%, 110.8%, 108.8%, 108.8%, 97.3% and 79.1% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
Pharmaceuticals (Basel). 2019 Jun 3 12(2). pii: E82. doi: 10.3390/ph12020082.