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Peptide record

TPDB02710

Antibacterial Cell-penetrating Peptides Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB02710
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CPPsite3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIKFFLKKLKKHI
Physicochemical Analysis
C80H134N20O14
ARNDCEQMPSTWYV
K
1600.07
11.12
6
0
6
+5
1.92
-0.069
120.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
2
I
2
L
5
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 2 L: 2 K: 5 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C80H134N20O14
1600.07
11.12
+5
1.92
-0.069
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 2 Activity

Activity

16% Killing
Toxicity
100 µg/mL
Cytotoxic
16% Killing | 100 | µg/mL | target cell: Mouse epithelial Hepa 1-6 cells

Target

Mouse epithelial Hepa 1-6 cells

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse epithelial Hepa 1-6 cells

Target

Mouse epithelial Hepa 1-6 cells

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31163671] 10% hemolysis at >100 µg/mL against human blood cells. | Cytotoxicity: [Ref.31163671] The cell viability of Hepa 1-6 induced by SP4 is 102.0%, 114.2%, 100.7%, 93.2%, 108.1% and 83.1% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
Pharmaceuticals (Basel). 2019 Jun 3 12(2). pii: E82. doi: 10.3390/ph12020082.