TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB02659

Peptide_Name

LL-37(1-12)

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

LLGDFFRKSKEK

FASTA

>TPDB02659|Antibacterial;Anticancer;Toxicity|length=12
LLGDFFRKSKEK

Formula C68H110N18O18

Absent Amino Acids ANCQHIMPTWYV

Common Amino Acids K

Mass 1467.73

PI 10.31

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 4

Net Charge +2

Boman Index 3.79

Hydrophobicity -0.933

Aliphatic Index 65.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

1

R

0

N

1

D

0

C

1

E

0

Q

1

G

0

H

0

I

2

L

3

K

0

M

2

F

0

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 3 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

12

Formula

C68H110N18O18

Mass

1467.73

PI

10.31

Net Charge

+2

Boman Index

3.79

Hydrophobicity

-0.933

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Linear

N_terminal_Modification

Free

Nature

Antibacterial

Origin

LL-37,a series of peptide fragments

Evidence 1 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Tumor

Cell Line KBv

Tissue Affected Not Available

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 2 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Oral Cancer

Cell Line KB

Tissue Affected Not Available

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 3 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Prostate Cancer

Cell Line HBMEC

Tissue Affected Not Available

Assay & Model

Assay MTT/MTS assay

Testing Time 24-h

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2006

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Human brain microvascular endothelial cells HBMEC

Target

Target Cell Human brain microvascular endothelial cells HBMEC

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. | J Am Chem Soc | 2006