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Peptide record

TPDB02654

Antibacterial Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB02654
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
ALWMTLLKKVLK
Physicochemical Analysis
C70H122N16O14S1
RNDCEQGHIFPSY
L
1443.90
10.84
3
0
8
+3
-1.31
0.817
162.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
380.91
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
3
K
1
M
0
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 3 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
12
C70H122N16O14S1
1443.90
10.84
+3
-1.31
0.817
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
50% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 2 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis