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Peptide record

TPDB02643

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB02643
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ILKKLLKGVKSI
Physicochemical Analysis
C64H122N16O14
ARNDCEQHMFPTWY
K
1339.77
11.00
4
0
6
+4
1.87
0.650
186.67
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
3
L
4
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C64H122N16O14
1339.77
11.00
+4
1.87
0.650
Evidence Records 1 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29379033] Hp1404-T1c does not induce substantial hemolysis, even at the high tested concentration (200 µM) against mouse red blood cells | Cytotoxicity: [Ref.29379033] The cell survial against HaCaT cells is 100%, 70%, 66% and 53% at peptide concentrations of 25, 50, 100 and 200 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2018 Jan 29 8(1):1763.