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Peptide record

TPDB02640

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB02640
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WKRRIKIWKKIR
Physicochemical Analysis
C82H139N27O13
ANDCEQGHLMFPSTYV
K
1711.18
12.72
7
0
5
+7
1.76
-1.450
97.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
642.83
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C82H139N27O13
1711.18
12.72
+7
1.76
-1.450
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
>256 µM
Cytotoxic
EC50 | >256 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. | Sci Rep | 2017
Evidence 2 Activity

Activity

EC50
Toxicity
>256 µM
Cytotoxic
EC50 | >256 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. | Sci Rep | 2017
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
50% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. | Sci Rep | 2017