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Peptide record

TPDB02627

Antibacterial Cell-penetrating Peptides Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB02627
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWIRWVWRKKLR
Physicochemical Analysis
C86H135N29O13
ANDCEQGHMFPSTY
R
1783.20
12.88
6
0
6
+6
-1.13
-1.333
89.17
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
925.30
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
2
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
12
C86H135N29O13
1783.20
12.88
+6
-1.13
-1.333
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>100 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 2 Activity

Activity

46% Killing
Toxicity
100 µg/mL
Cytotoxic
46% Killing | 100 | µg/mL | target cell: Mouse epithelial Hepa 1-6 cells

Target

Mouse epithelial Hepa 1-6 cells

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 3 Activity

Activity

5% Killing
Toxicity
50 µg/mL
Cytotoxic
5% Killing | 50 | µg/mL | target cell: Mouse epithelial Hepa 1-6 cells

Target

Mouse epithelial Hepa 1-6 cells

Source & Reference

NA
DBAASP
De Novo Design and In Vitro Testing of Antimicrobial Peptides against Gram-Negative Bacteria. | Pharmaceuticals (Basel) | 2019
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31163671] 10% hemolysis at >100 µg/mL against human blood cells. | Cytotoxicity: [Ref.31163671] The cell viability of Hepa 1-6 induced by SP15 is 90.5%, 90.5%, 89.2%, 83.1%, 93.2% and 52.7% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 µg/mL.

Target

erythrocytes

Source & Reference

NA
DRAMP
Pharmaceuticals (Basel). 2019 Jun 3 12(2). pii: E82. doi: 10.3390/ph12020082.