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Peptide record

TPDB02592

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB02592
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP dbAMP 3.0 PD_Hemolysis
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKKV
Physicochemical Analysis
C59H102N14O12
RNDCEQGHIMFPSY
LK
1199.55
10.84
3
0
6
+3
-0.52
0.410
156.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
458.51
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
3
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
10
C59H102N14O12
1199.55
10.84
+3
-0.52
0.410
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity | J Biol Chem | 2000
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>50 µM
Hemolytic Cytotoxic
50% Hemolysis | >50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives. | J Biol Chem | 2002
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis