TPDB

3D PDB MODEL

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TPDB ID TPDB02566

Activity

Antibacterial Anticancer Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.

Sequence

LLLKKFKKLQ

FASTA

>TPDB02566|Antibacterial;Anticancer;Hemolysis;Toxicity|length=10
LLLKKFKKLQ

Formula C62H111N15O12

Absent Amino Acids ARNDCEGHIMPSTWYV

Common Amino Acids LK

Mass 1258.66

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +4

Boman Index 1.17

Hydrophobicity -0.110

Aliphatic Index 156.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

4

L

4

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C62H111N15O12

Mass

1258.66

PI

11.00

Net Charge

+4

Boman Index

1.17

Hydrophobicity

-0.110

Evidence 1 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 6.5 %

Hemolysis Raw

Human erythrocytes: 87 ± 6.5% Hemolysis=375 µM

Target

RBC Target Human erythrocytes

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Peptides. 2010 Nov 31(11):2017-26

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 87% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 375 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

87% Hemolysis | 375 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 3 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 6.5 %

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: 87 ± 6.5% Hemolysis=375 µM | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2010 Nov 31(11):2017-26

Evidence 4 Hemolysis

Activity

Activity Measurement 6.5 %

Activity Endpoint % Hemolysis

Hemolysis Raw

Human erythrocytes: 87 ± 6.5% Hemolysis=375 µM

Detail Source Activity Hemolysis

Target

RBC Target Human erythrocytes

Source & Reference

source HemoPI PD_Hemolysis

Reference

Peptides. 2010 Nov 31(11):2017-26

Source DRAMP4

Database Source PD_Hemolysis