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Peptide record

TPDB02546

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB02546
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WRYQWTILFI
Physicochemical Analysis
C73H100N16O14
ANDCEGHKMPSV
IW
1425.70
9.88
1
0
7
+1
-5.42
0.380
117.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
12490
876.06
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
1
L
0
K
0
M
1
F
0
P
0
S
1
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 0
Chemical Descriptors
10
C73H100N16O14
1425.70
9.88
+1
-5.42
0.380
Evidence Records 2 records
Evidence 1 Activity

Activity

7% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
7% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery and characterization of New Delhi metallo-beta-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae. | J Antimicrob Chemother | 2020
Evidence 2 Activity

Activity

5% Killing
Toxicity
256 µM
Cytotoxic
5% Killing | 256 | µM | target cell: Murine intestinal epithelial cells MODE-K

Target

Murine intestinal epithelial cells MODE-K

Source & Reference

NA
DBAASP
Discovery and characterization of New Delhi metallo-beta-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae. | J Antimicrob Chemother | 2020